http://aging.wiki/w/index.php?action=history&feed=atom&title=List_of_cool_modern_papersList of cool modern papers - Revision history2026-05-17T13:05:07ZRevision history for this page on the wikiMediaWiki 1.39.1http://aging.wiki/w/index.php?title=List_of_cool_modern_papers&diff=71&oldid=prevAdmin: 1 revision imported2024-06-07T01:05:11Z<p>1 revision imported</p>
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<p><b>New page</b></p><div>https://pubmed.ncbi.nlm.nih.gov/34012082/ (19 May 2021) <br/><br />
In living macaques, CRISPR was used to edit ~66% of liver cells by introducing a single nucleotide mutation in the gene PCSK9. This caused their LDL cholesterol to drop by 60% and stay that way for at least 8 months (no further tests yet). <br/><br />
Off-target mutations were only at one site with a frequency of <1%. In humans, a similar mutation in PCSK9 would lead to a reduced chance of developing atherosclerosis-related diseases. <br/><br />
The entire procedure consisted of a single injection of lipid nanoparticles containing CRISPR into the blood. <br/><br />
Here was used a variant of CRISPR which can replace only one base, without double-stranded DNA breaks. <br/><br />
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Authors transplanted a pig kidney into a rhesus macaque for as long as 435 days: <br/><br />
https://www.nature.com/articles/s41586-018-0765-z</div>Admin