List of cool modern papers

https://pubmed.ncbi.nlm.nih.gov/34012082/ (19 May 2021)
In living macaques, CRISPR was used to edit ~66% of liver cells by introducing a single nucleotide mutation in the gene PCSK9. This caused their LDL cholesterol to drop by 60% and stay that way for at least 8 months (no further tests yet).
Off-target mutations were only at one site with a frequency of <1%. In humans, a similar mutation in PCSK9 would lead to a reduced chance of developing atherosclerosis-related diseases.
The entire procedure consisted of a single injection of lipid nanoparticles containing CRISPR into the blood.
Here was used a variant of CRISPR which can replace only one base, without double-stranded DNA breaks.

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Authors transplanted a pig kidney into a rhesus macaque for as long as 435 days:
https://www.nature.com/articles/s41586-018-0765-z